Services
Preclinical CNS Disease Models
Stereotactic Neurosurgery & In Vivo Methodologies
Neurohistology, Neurochemistry & Biomarker Analysis
CORE CAPABILITIES
Integrated Preclinical Neuroscience Expertise
Motac Neuroscience designs and conducts bespoke preclinical studies for pharmaceutical and biotechnology companies developing new treatments for central nervous system disorders.
Our scientists combine internationally recognised expertise in neuroanatomy, neurophysiology, neuropharmacology and neuropsychology with flexible study design, translational disease models and expert data interpretation.
CNS Disease Models & Functional Assessment
Disease-relevant preclinical models of Parkinson’s disease, multiple system atrophy, dementia with Lewy bodies, Alzheimer’s disease, progressive supranuclear palsy, Huntington’s disease, amyotrophic lateral sclerosis, cognitive disorders and spinal cord injury. Studies can integrate motor performance, behavioural assessment, CANTAB-based cognitive testing, sleep, vigilance and attention endpoints.
Stereotactic Neurosurgery & In Vivo Methodologies
Advanced stereotactic neurosurgery in rodents, pigs and non-human primates (NHP), including intracerebral delivery, brain microdialysis, PK/PD studies and chronic in vivo calcium imaging.
Neurohistology, Neurochemistry & Biomarker Analysis
Integrated behavioural, neurochemical and post-mortem endpoints, including neurohistology, immunohistochemistry, stereology, neurochemistry, neurobiochemistry, HPLC analysis and quantitative biomarker measurement.
THERAPEUTIC FOCUS
Key Application Areas
Parkinson's Disease &
Movement Disorders
Rodent and non-human primate (NHP) models for Parkinson's disease, dyskinesia, motor fluctuations, tremor, neurodegeneration, neuroprotection and neurorestoration.
Synucleinopathies
Alpha-synuclein models for Parkinson's disease, dementia with Lewy bodies and multiple system atrophy, including seeding and preformed fibril approaches.
Alzheimer's Disease & Tauopathies
Preclinical models of Alzheimer's disease and tauopathies, including amyloid-beta-induced memory impairment and tau seeding studies.
Cognitive Disorders & Neuropsychology
Translational cognitive assessment using aged macaque and scopolamine models, CANTAB-based testing, object retrieval tasks, memory and attention endpoints.
ALS & Spinal Cord Injury
Preclinical models and functional endpoints for amyotrophic lateral sclerosis and spinal cord injury, including motor, kinematic and anatomical assessment.
Huntington's Disease & Other Proteinopathies
Expertise in Huntington's disease and other proteinopathies, supported by tailored behavioural, biochemical, neurochemical and histopathological read-outs.
Advance your preclinical programme
Discuss your next preclinical study with our scientific team and accelerate its progression towards proof of concept.
